Hydrochloric Acid → HCID 86590342, compound

HRID 2055578Notes

Reaction equation

HRID 2055578 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]([NH:10]C(=O)OC(C)(C)C)[CH3:9])=[C:4]([F:18])[CH:3]=1.[ClH:19]>C(OCC)(=O)C>[Cl-:19].[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]([NH3+:10])[CH3:9])=[C:4]([F:18])[CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 16102911HCID 16102911, compound

Product 1

HCID 86590342HCID 86590342, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Tert-butyl(1R)-1-(4-bromo-2-fluorophenyl)ethylcarbamate (10.04 g, 31.55 mmol) was dissolved in ethyl acetate and treated with hydrochloric acid gas. A white solid precipitated and the suspension was concentrated under reduced pressure to yield (1R)-1-(4-bromo-2-fluorophenyl)ethanaminium chloride as a white solid that was used without further purification. Low resolution mass spectrometry: (M+H+−NH3)=201.1.

Workup

  1. customA white solid precipitated
  2. concentrationthe suspension was concentrated under reduced pressure

Sources & evidence

ORD record
ord-812a16859b154c8088ed5afafdf3f98f
Source dataset
uspto-grants-2008_02
Patent number
US07332499B2

Reaction notes

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