Trimethylsilylacetylene → HCID 72741377, compound

HRID 2055836Notes

Reaction equation

HRID 2055836 reaction equation
Cl/[CH:2]=[CH:3]\[C:4]#[C:5][CH2:6][CH2:7][CH2:8][CH3:9].[CH3:10][Si:11]([C:14]#[CH:15])([CH3:13])[CH3:12]>[Pd]>[CH3:10][Si:11]([CH3:13])([CH3:12])[C:14]#[C:15][CH:2]=[CH:3][C:4]#[C:5][CH2:6][CH2:7][CH2:8][CH3:9]

Participants

4

Reactant 2

HCID 66111TrimethylsilylacetyleneHCID 11062498HCID 11062498, compound

Product 1

HCID 72741377HCID 72741377, compoundYield 53%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

According to Method A of the above-described General Synthesis Procedures I, the coupling reaction of compound (a4) from Example 4 with trimethylsilylacetylene using palladium as a catalyst gave the title compound (a5) as an oil in 53% yield.

Workup

  1. customAccording to Method A of the above-described General Synthesis Procedures I

Sources & evidence

ORD record
ord-ef28960aa8f44053b2bcad6e6cdc3b22
Source dataset
uspto-grants-2008_02
Patent number
US07332623B2

Reaction notes

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