Ethanol → 7,7,9,9-Tetramethyl-1,3,8-triazaspiro[4.5]decane-2,4-dione

HRID 2056233Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2056233
[CH3:1][C:2]1([CH3:11])[CH2:7][C:6](=O)[CH2:5][C:4]([CH3:10])([CH3:9])[NH:3]1.[C-]#N.[K+].[C:15](=[O:18])([O-])[O-].[NH4+:19].[NH4+:20].[CH2:21]([OH:23])C>O>[CH3:1][C:2]1([CH3:11])[NH:3][C:4]([CH3:10])([CH3:9])[CH2:5][C:6]2([NH:20][C:21](=[O:23])[NH:19][C:15]2=[O:18])[CH2:7]1

Komponenten

6

Edukt 4

HCID 702EthanolHCID 9032Potassium CyanideHCID 132202,2,6,6-Tetramethyl-4-piperidoneHCID 517111Ammonium Carbonate

Produkt 1

HCID 12680667,7,9,9-Tetramethyl-1,3,8-triazaspiro[4.5]decane-2,4-dione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Reaktionsbedingungen

Temperatur
85 °C

Versuchsvorschrift

In a Parr high-pressure reactor, 15.6 grams (0.1 mol) of 2,2,6,6-tetramethyl-4-piperidone (Aldrich Chemicals Inc.), 13.5 grams (0.2 mol) of 97% potassium cyanide, 43.2 grams (0.45 mol) of ammonium carbonate, 120 mL ethanol, and 120 mL water were mixed. The contents were reacted with stirring at 85° C. for 12 hours, cooled to ambient temperature, and poured into 300 mL of water causing the solid product to precipitate. Impurity salts were washed away with water, and the product was dried.

Aufarbeitung

  1. customThe contents were reacted
  2. temperaturecooled to ambient temperature
  3. customto precipitate
  4. washImpurity salts were washed away with water
  5. customthe product was dried

Quellen und Nachweise

ORD-Eintrag
ord-2447af17aa6d41f8857e7de17787302a
Quelldatensatz
uspto-grants-2008_02
Patentnummer
US07335373B2

Notizen zur Reaktion

Wird geladen…