m-Chloroperbenzoic acid → HCID 11574672, compound

HRID 2056694Notes

Reaction equation

HRID 2056694 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:16]=[C:15](SC)[N:14]=[C:13]([NH:19][C:20]3[CH:29]=[CH:28][C:23]4[O:24][CH2:25][CH2:26][O:27][C:22]=4[CH:21]=3)[CH:12]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].C1C=C(Cl)C=C([C:37](OO)=[O:38])C=1>C(Cl)Cl>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:16]=[C:15]([O:38][CH3:37])[N:14]=[C:13]([NH:19][C:20]3[CH:29]=[CH:28][C:23]4[O:24][CH2:25][CH2:26][O:27][C:22]=4[CH:21]=3)[CH:12]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 58612014HCID 58612014, compound

Product 1

HCID 11574672HCID 11574672, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a 50-mL, round-bottomed flask containing a solution of 6-(4-tert-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-(methylthio)pyrimidin-4-amine from step (b) above (0.41 g, 1.0 mmol) in CH2Cl2 (10 mL) was added m-CPBA (0.38 g, 2.2 mmol, Aldrich). The reaction mixture was stirred at room temperature for 0.5 h, and the solvent was removed in vacuo. The residue was dried in vacuo to provide the title product. MS (ESI, pos. ion) m/z: 439 (M+1).

Workup

  1. customthe solvent was removed in vacuo
  2. customThe residue was dried in vacuo

Sources & evidence

ORD record
ord-cb3d9aaa08ae409bb5e89aadab40034c
Source dataset
uspto-grants-2008_02
Patent number
US07335672B2

Reaction notes

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