反应详情

A solution of ethyl 3-fluoro-4-(3-[(1S)-2-hydroxy-1-methylethoxy]-5-{[(1-methyl-1H-pyrazol-3-yl)amino]carbonyl}phenoxy)benzoate (1.8 g, 3.94 mmol) in THF (60 mL) was added to a solution of lithium hydroxide monohydrate (0.83 g, 19.7 mmol) in water (30 mL). The mixture was stirred at RT for 72 hours and the THF removed in vacuo. The aqueous layer was extracted into ethyl acetate (100 mL) to remove any impurities, then acidified with 1M hydrochloric acid and extracted into ethyl acetate (2×100 mL). The combined extracts were dried (MgSO4) and the solvent removed in vacuo to give the desired compound (1.62 g).

1. customthe THF removed in vacuo
2. extractionThe aqueous layer was extracted into ethyl acetate (100 mL)
3. customto remove any impurities
4. extractionextracted into ethyl acetate (2×100 mL)
5. dry with materialThe combined extracts were dried (MgSO4)
6. customthe solvent removed in vacuo