Trifluoroacetic acid → HCID 178463962, compound

HRID 2057289Notes

Reaction equation

HRID 2057289 reaction equation
[CH3:1][NH:2][C@H:3]1[CH2:8][CH2:7][C@H:6]([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]OS(C)(=O)=O)[CH2:5][CH2:4]1.FC(F)(F)C(O)=O.[F:26][C:27]([F:39])([F:38])[C:28]1[CH:33]=[CH:32][C:31]([S:34](Cl)(=[O:36])=[O:35])=[CH:30][CH:29]=1.[CH2:40]([NH:42][CH2:43][CH3:44])[CH3:41]>>[CH2:40]([N:42]([CH2:43][CH3:44])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][C@H:6]1[CH2:5][CH2:4][C@H:3]([N:2]([CH3:1])[S:34]([C:31]2[CH:32]=[CH:33][C:28]([C:27]([F:39])([F:38])[F:26])=[CH:29][CH:30]=2)(=[O:36])=[O:35])[CH2:8][CH2:7]1)[CH3:41]

Participants

5

Reactant 4

HCID 6422Trifluoroacetic acidHCID 8021DiethylamineHCID 27773994-(Trifluoromethyl)benzenesulfonyl chlorideHCID 178484796HCID 178484796, compound

Product 1

HCID 178463962HCID 178463962, compound

Procedure

In analogy to examples 29.10 and 29.11, trans-Methansulfonic acid 5-(4-methyl amino-cyclohexyl)-pentyl ester.Trifluoroacetic acid salt and 4-trifluoromethyl-phenyl sulfonylchloride were reacted, followed by treatment with diethylamine to give trans N-[4-(5-Diethylamino-pentyl)-cyclohexyl]-N-methyl-4-trifluoromethyl-benzenesulfonamide. MS: 463 (MH+).

Sources & evidence

ORD record
ord-90eedba072c6407e85358e5285bf8c32
Source dataset
uspto-grants-2008_02
Patent number
US07335687B2

Reaction notes

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