Trifluoroacetic acid → HCID 178484798, compound

HRID 2057303Notes

Reaction equation

HRID 2057303 reaction equation
[CH3:1][NH:2][C@H:3]1[CH2:8][CH2:7][C@H:6]([CH2:9][CH2:10][CH2:11][CH2:12]OS(C)(=O)=O)[CH2:5][CH2:4]1.FC(F)(F)C(O)=O.[F:25][C:26]([F:38])([F:37])[C:27]1[CH:32]=[CH:31][C:30]([S:33](Cl)(=[O:35])=[O:34])=[CH:29][CH:28]=1.[NH:39]1[CH2:44][CH2:43][CH2:42][CH2:41][CH2:40]1>>[CH3:1][N:2]([C@H:3]1[CH2:4][CH2:5][C@H:6]([CH2:9][CH2:10][CH2:11][CH2:12][N:39]2[CH2:44][CH2:43][CH2:42][CH2:41][CH2:40]2)[CH2:7][CH2:8]1)[S:33]([C:30]1[CH:31]=[CH:32][C:27]([C:26]([F:38])([F:37])[F:25])=[CH:28][CH:29]=1)(=[O:35])=[O:34]

Participants

5

Reactant 4

HCID 6422Trifluoroacetic acidHCID 8082PiperidineHCID 27773994-(Trifluoromethyl)benzenesulfonyl chlorideHCID 178484800HCID 178484800, compound

Product 1

HCID 178484798HCID 178484798, compound

Procedure

In analogy to examples 31.5 and 31.6, trans-Methanesulfonic acid 4-(4-methylamino-cyclohexyl)-butyl ester.trifluoro-acetic acid and 4-trifluoromethyl-phenyl-sulfonylchloride were reacted, followed by treatment with piperidine to give trans-N-Methyl-N-[4-(4-piperidin-1-yl-butyl)-cyclohexyl]-4-trifluoromethyl-benzenesulfonamide, MS: 461 (MH+).

Sources & evidence

ORD record
ord-cae99b3787534393adcae01f771076c3
Source dataset
uspto-grants-2008_02
Patent number
US07335687B2

Reaction notes

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