Dibenzylamine → HCID 54369477, compound

HRID 2057380Notes

Reaction equation

HRID 2057380 reaction equation
Cl[CH2:2][C:3]([N:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[C:9](=[O:16])[NH:8][C:7]2[CH:17]=[CH:18][CH:19]=[N:20][C:6]1=2)=[O:4].[CH2:21]([NH:28][CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.C(N(CC)CC)C>O1CCOCC1>[CH2:29]([N:28]([CH2:2][C:3]([N:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[C:9](=[O:16])[NH:8][C:7]2[CH:17]=[CH:18][CH:19]=[N:20][C:6]1=2)=[O:4])[CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1

Participants

5

Reactant 3

HCID 7656DibenzylamineHCID 8471TriethylamineHCID 12005311-(Chloroacetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one

Product 1

HCID 54369477HCID 54369477, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

6 gm of 11-chloroacetyl-5,11-dihydro-6H-pyrido [2,3-b][1,4]benzodiazepin-6-one, 4.2 gm of dibenzylamine and 2.1 gm of triethylamine were refluxed in 100 ml of absolute dioxane for 15 hours. After cooling, the formed triethylamine hydrochloride was separated, and the filtrate was evaporated in vacuo to dryness. The residue was then recrystallized twice from ethanol.

Workup

  1. temperatureAfter cooling
  2. customthe formed triethylamine hydrochloride was separated
  3. customthe filtrate was evaporated in vacuo to dryness
  4. customThe residue was then recrystallized twice from ethanol

Sources & evidence

ORD record
ord-f0e29213d85840048aac31dfe0430df4
Source dataset
uspto-grants-1980_07
Patent number
US04210648

Reaction notes

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