Diethylamine → HCID 20332027, compound

HRID 2057385Notes

Reaction equation

HRID 2057385 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][C:5]([N:7]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[C:11](=[O:18])[N:10]([CH3:19])[C:9]2[CH:20]=[CH:21][CH:22]=[N:23][C:8]1=2)=[O:6].[CH2:24]([NH:26][CH2:27][CH3:28])[CH3:25]>CN(C)C=O>[ClH:1].[CH2:24]([N:26]([CH2:27][CH3:28])[CH2:2][CH2:3][CH2:4][C:5]([N:7]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[C:11](=[O:18])[N:10]([CH3:19])[C:9]2[CH:20]=[CH:21][CH:22]=[N:23][C:8]1=2)=[O:6])[CH3:25]

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 20332031HCID 20332031, compound

Product 1

HCID 20332027HCID 20332027, compoundYield 54%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

4.3 gm of 11-(4-chlorobutyryl)-5,11-dihydro-5-methyl-6H-pyrido-[2,3-b][1,4]benzodiazepin-6-one and 1.9 gm of diethylamine were allowed to stand in 70 ml of dimethylformamide for 3 weeks at room temperature. Then the reaction mixture was evaporated in vacuo to dryness, and the residue was recrystallized from isopropanol. The hydrochloride, M.p.: 233°-235° C., was obtained.

Workup

  1. customThen the reaction mixture was evaporated in vacuo to dryness
  2. customthe residue was recrystallized from isopropanol

Sources & evidence

ORD record
ord-45ddab4909094593b47a3cf4abd24072
Source dataset
uspto-grants-1980_07
Patent number
US04210648

Reaction notes

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