Pyrrolidine → HCID 20332023, compound

HRID 2057389Notes

Reaction equation

HRID 2057389 reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH2:5][C:6]([N:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[C:12](=[O:19])[NH:11][C:10]2[CH:20]=[CH:21][CH:22]=[N:23][C:9]1=2)=[O:7].[NH:24]1[CH2:28][CH2:27][CH2:26][CH2:25]1>C(O)C>[N:24]1([CH2:2][CH2:3][CH2:4][CH2:5][C:6]([N:8]2[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=3[C:12](=[O:19])[NH:11][C:10]3[CH:20]=[CH:21][CH:22]=[N:23][C:9]2=3)=[O:7])[CH2:28][CH2:27][CH2:26][CH2:25]1

Participants

4

Reactant 2

HCID 31268PyrrolidineHCID 20329396HCID 20329396, compound

Product 1

HCID 20332023HCID 20332023, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4.5 gm of 11-(5-chlorovaleryl)-5,11-dihydro-6H-pyrido [2,3-b][1,4]-benzodiazepin-6-one and 10 ml of pyrrolidine were refluxed in 100 ml of ethanol for 12 hours. The alcohol was then distilled off, the residue was dissolved in chloroform/water, the organic phase was evaporated in vacuo to dryness, and the residue was recrystallized from ethyl acetate.

Workup

  1. distillationThe alcohol was then distilled off
  2. dissolutionthe residue was dissolved in chloroform/water
  3. customthe organic phase was evaporated in vacuo to dryness
  4. customthe residue was recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-3c6e3a6d237048aa99cf7b1ea0c3de44
Source dataset
uspto-grants-1980_07
Patent number
US04210648

Reaction notes

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