Aluminium lithium hydride → HCID 23312291, compound

HRID 2057418Notes

Reaction equation

HRID 2057418 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([C:10]2[O:11][C:12]3[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=3[CH:14]=2)[CH2:6][CH2:5]1)(=O)[CH3:2].[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH2:1]([N:4]1[CH2:9][CH2:8][CH:7]([C:10]2[O:11][C:12]3[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=3[CH:14]=2)[CH2:6][CH2:5]1)[CH3:2]

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 23312335HCID 23312335, compound

Product 1

HCID 23312291HCID 23312291, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

Analogously to Example 10, 8.0 g of 1-acetyl-4-(2-benzofuranyl)-piperidine in 100 ml of tetrahydrofuran is reduced with 12.0 g of lithium aluminium hydride in 150 ml of tetrahydrofuran, whereby the reaction mixture is refluxed for 15 hours. The crude 1-ethyl-4-(2-benzofuranyl)-piperidine obtained is converted into the hydrochloride which, after recrystallisation from ethyl acetate, melts at 198°.

Workup

  1. temperatureis refluxed for 15 hours

Sources & evidence

ORD record
ord-aa2eee4e95e54096993090db691ebfbc
Source dataset
uspto-grants-1980_07
Patent number
US04210655

Reaction notes

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