反应详情

温度

20 °C

The 2-amino-3:5-dinitrothiophene used in the above Example was obtained by reacting the sodium salt of cyanoacetic acid with the dimer of mercaptoacetaldehyde in aqueous medium at 80° C., cooling to 20° C., adding acetic anhydride whilst maintaining the pH of the mixture between 6 and 7, acidifying and isolating the 2-acetylaminothiophene-3-carboxylic acid. This was then dinitrated in sulphuric acid medium at 0° C., the resulting 2-acetylamino-3:5-dinitrothiophene isolated and then deacylated by heating in an aqueous solution of sulphuric acid.

1. customwas obtained
2. customat 80° C.
3. temperaturewhilst maintaining the pH of the mixture between 6 and 7