反应详情

To a stirred solution of 80.1 g. of 2-octylthiophene in 70 ml. dimethylformamide is added dropwise 42.4 ml. of phosphorus oxychloride. After addition, the solution is made warmed at 100° for 1 hour, then poured into 600 ml. ice. After neutralization with sodium acetate, the resulting oil is extracted with ether. The ether is washed with water and aqueous potassium carbonate, dried, and distilled in vacuo to give the title compound as an oil.

1. additionAfter addition
2. temperaturethe solution is made warmed at 100° for 1 hour
3. additionpoured into 600 ml
4. extractionAfter neutralization with sodium acetate, the resulting oil is extracted with ether
5. washThe ether is washed with water and aqueous potassium carbonate
6. customdried
7. distillationdistilled in vacuo