2-Pyridinecarboxaldehyde → HCID 78605778, compound

HRID 2057744Notes

Reaction equation

HRID 2057744 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]=O.Cl.[Cl:10][C:11]1[CH:16]=[CH:15][C:14]([NH:17][NH2:18])=[CH:13][CH:12]=1.C([O-])(=O)C.[Na+]>C(O)C>[Cl:10][C:11]1[CH:16]=[CH:15][C:14]([NH:17][N:18]=[CH:7][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)=[CH:13][CH:12]=1

Participants

5

Reactant 3

HCID 142732-PyridinecarboxaldehydeHCID 71600Hydrazine, (4-chlorophenyl)-, hydrochloride (1:1)HCID 517045Sodium Acetate

Product 1

HCID 78605778HCID 78605778, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.2 g of 2-pyridinecarbaldehyde was added to a mixture of 3.6 g of p-chlorophenylhydrazine hydrochloride and 9.8 g of sodium acetate in 60 ml of 50% by volume aqueous ethyl alcohol. The mixture was refluxed for 10 minutes, cooled and the precipitate crystallized from ethyl alcohol to give 2, as yellow crystals, mp 184°-186° C.

Workup

  1. temperatureThe mixture was refluxed for 10 minutes
  2. temperaturecooled
  3. customthe precipitate crystallized from ethyl alcohol
  4. customto give 2

Sources & evidence

ORD record
ord-f03605f405c94c128ebbb79d84968ac5
Source dataset
uspto-grants-1980_07
Patent number
US04212868

Reaction notes

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