2-Amino-5-chloropyridine → HCID 23345083, compound

HRID 2057748Notes

Reaction equation

HRID 2057748 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][N:3]=1.[Cl:9][C:10]1[CH:20]=[CH:19][CH:18]=[C:17]([Cl:21])[C:11]=1[C:12]([N:14]=[C:15]=[O:16])=[O:13]>C(OCC)(=O)C>[Cl:9][C:10]1[CH:20]=[CH:19][CH:18]=[C:17]([Cl:21])[C:11]=1[C:12]([NH:14][C:15]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][N:3]=1)=[O:16])=[O:13]

Participants

4

Reactant 2

HCID 661742-Amino-5-chloropyridineHCID 129127392,6-Dichlorobenzoyl isocyanate

Product 1

HCID 23345083HCID 23345083, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To a suspension of 16.7 g (0.13 mole) of 2-amino-5-chloropyridine in 250 ml of ethyl acetate was added all at once a solution of 30.0 g (0.14 mole) of 2,6-dichlorobenzoyl isocyanate in ethyl acetate. The mixture was allowed at 25° for six hours. Filtration gave 36.3 g (85%) of 1-(2,6-dichlorobenzoyl)-3-(5-chloro-2-pyridinyl)urea, m.p. 220-222°.

Workup

  1. filtrationFiltration

Sources & evidence

ORD record
ord-431cb9638ef0402ab428c75fa79fe85d
Source dataset
uspto-grants-1980_07
Patent number
US04212870

Reaction notes

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