Water → HCID 131711807, compound

HRID 2057846Notes

Reaction equation

HRID 2057846 reaction equation
[NH2:1][C@H:2]([C:24]([NH:26][C@H:27]([C:30]([NH:32][C@H:33]([C:38]([OH:40])=[O:39])[CH2:34][CH:35]([CH3:37])[CH3:36])=[O:31])[CH2:28][OH:29])=[O:25])[CH2:3][S:4]C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.O.O.[F:43][C:44]([F:49])([F:48])[C:45]([OH:47])=[O:46]>C(S)C>[NH2:1][C@H:2]([C:24]([NH:26][C@H:27]([C:30]([NH:32][C@H:33]([C:38]([OH:40])=[O:39])[CH2:34][CH:35]([CH3:37])[CH3:36])=[O:31])[CH2:28][OH:29])=[O:25])[CH2:3][SH:4].[F:43][C:44]([C:45]([OH:47])=[O:46])([F:49])[F:48]

Participants

5

Reactant 3

HCID 962WaterHCID 6422Trifluoroacetic acidHCID 131711809HCID 131711809, compound

Product 1

HCID 131711807HCID 131711807, compound

Reagents, catalysts & solvents 1

HCID 6343EthanethiolSolvent

Procedure

564 mg (0.97 mmole) of H-Cys(Trt)-Ser-Leu-OH.H2O (Chem. Ber. 103, 2034 (1970)) are dissolved in a mixture of 2.5 ml of ethylmercaptan and 2.5 ml of trifluoroacetic acid. The mixture is left to stand for 30 minutes at room temperature and the batch is poured into 50 ml of water. The aqueous phase is extracted three times with ether and is freeze-dried.

Workup

  1. waitThe mixture is left
  2. extractionThe aqueous phase is extracted three times with ether
  3. customis freeze-dried

Sources & evidence

ORD record
ord-14f9a0c92aed426f97fc6f516fcae75d
Source dataset
uspto-grants-1980_07
Patent number
US04212796

Reaction notes

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