Hydrochloric Acid → H-Thr(But)-Ser(But)-OH.HCl

HRID 2057852Notes

Reaction equation

HRID 2057852 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:10]([NH:12][C@H:13]([C:20]([OH:22])=[O:21])[CH2:14][O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:11])[C@@H:3]([CH3:9])[O:4][C:5]([CH3:8])([CH3:7])[CH3:6].[ClH:33]>CO>[NH2:1][C@H:2]([C:10]([NH:12][C@H:13]([C:20]([OH:22])=[O:21])[CH2:14][O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:11])[C@@H:3]([CH3:9])[O:4][C:5]([CH3:8])([CH3:7])[CH3:6].[ClH:33]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 129820266Z-Thr(But)-Ser(But)OH

Product 1

HCID 131711820H-Thr(But)-Ser(But)-OH.HCl

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

25 g (55.24 mmoles) of Z-Thr(But)-Ser(But)-OH are dissolved in 200 ml of methanol and are hydrogenated catalytically (at pH 4.5) using an autotitrator, with addition of a solution of HCl in methanol. After completion of the hydrogenation, the Pd/BaSO4 catalyst is filtered off, the filtrate is concentrated and the residue is dried in a high vacuum. Yield 1.1 g of an amorphous product

Workup

  1. filtrationAfter completion of the hydrogenation, the Pd/BaSO4 catalyst is filtered off
  2. concentrationthe filtrate is concentrated
  3. customthe residue is dried in a high vacuum

Sources & evidence

ORD record
ord-5202ccddff8844388f38367cc7dcc128
Source dataset
uspto-grants-1980_07
Patent number
US04212796

Reaction notes

Loading…