Hydrochloric Acid → HCID 86737097, compound

HRID 2057870Notes

Reaction equation

HRID 2057870 reaction equation
[CH3:1][N:2]1[C:6]([C:7]([C:9]2[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][CH:10]=2)=[O:8])=[CH:5][CH:4]=[C:3]1[CH2:16][C:17]([OH:19])=[O:18].[Na].CN1C(C(C2C=CC(C)=CC=2)=O)=CC=C1CC#N.C([SH:41])C.Cl>>[CH2:16]([C:3]1[N:2]([CH3:1])[C:6]([C:7]([C:9]2[CH:10]=[CH:11][C:12]([CH3:15])=[CH:13][CH:14]=2)=[O:8])=[CH:5][CH:4]=1)[CH3:17].[S:41]1[CH:6]=[CH:5][CH:4]=[C:3]1[CH2:16][C:17]([O-:19])=[O:18]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 6343EthanethiolHCID 111074051-Methyl-5-(p-toluoyl)pyrrole-2-acetonitrileHCID 6658458735711-34-3

Product 1

HCID 86737097HCID 86737097, compound

Procedure

A process of preparing sodium 1-methyl-5-(p-toluoyl)- pyrrole-2-acetic acid which comprises reacting 1-methyl-5- (p-toluoyl)pyrrole-2-acetonitrile with ethyl mercaptan in the presence of hydrogen chloride in an anhydrous aprotic organic solvent under an inert atmosphere at or below 10° C. to yield ethyl 1-methyl-5-(p-toluoyl)pyrrole-2-thiolacetate and then hydrolyzing said thiolacetate by treatment with aqueous sodium hydroxide.

Workup

  1. custombelow 10° C.

Sources & evidence

ORD record
ord-46cfd9a08d82413495c18df103be3179
Source dataset
uspto-grants-1980_07
Patent number
US04213905

Reaction notes

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