Hydrochloric Acid → HCID 86737100, compound

HRID 2057885Notes

Reaction equation

HRID 2057885 reaction equation
[ClH:1].[NH2:2][C@H:3]([C:6]([OH:8])=[O:7])[CH2:4][SH:5].Cl.[CH2:10](O)[CH2:11][CH2:12][CH2:13][CH2:14][CH3:15]>>[ClH:1].[CH2:10]([O:7][C:6](=[O:8])[C@H:3]([CH2:4][SH:5])[NH2:2])[CH2:11][CH2:12][CH2:13][CH2:14][CH3:15]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 81031-HexanolHCID 60960Cysteine Hydrochloride

Product 1

HCID 86737100HCID 86737100, compound

Procedure

L-Cysteine hydrochloride 78.5 g was added to 150 ml of hexanol saturated with dry HCl gas. The mixture was heated under reflux overnight. The solution was evaporated to about half of the total volume, ethyl ether 150 ml was added. The solution gave crystals when it was cooled. Crystals were filtered and were recrystallized from ethyl acetate; yield 45 g; mp 89°-90° C.; IR (KBr) 1745 cm-1 ; NMR (CDCl3) δ 9.2-8.4 (b, 3, NH3⊕), 4.7 (5, 1, --CH--), 4.3 (t, 2, --OCH2 --), 3.4 (b, 2, CH2S--), 1.0-3.0 (m, 8), 1.0 (t, 3-, CH5).

Workup

  1. temperatureThe mixture was heated
  2. temperatureunder reflux overnight
  3. customThe solution was evaporated to about half of the total volume, ethyl ether 150 ml
  4. additionwas added
  5. customThe solution gave crystals when it
  6. temperaturewas cooled
  7. filtrationCrystals were filtered
  8. customwere recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-6b95522d4f59488ea10c95e0babef77b
Source dataset
uspto-grants-1980_07
Patent number
US04213978

Reaction notes

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