Hydrochloric Acid → HCID 178420815, compound

HRID 2057893Notes

Reaction equation

HRID 2057893 reaction equation
COC[N:4]1[CH:8]=[CH:7][N:6]=[C:5]1[CH2:9][C:10]1[NH:14][N:13]=[N:12][N:11]=1.O.Cl.[O-]CC.[Na+]>C(O)(=O)C>[NH:14]1[C:10]([CH2:9][C:5]2[NH:6][CH:7]=[CH:8][N:4]=2)=[N:11][N:12]=[N:13]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 2723922Sodium ethoxideHCID 178496772HCID 178496772, compound

Product 1

HCID 178420815HCID 178420815, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

8.14 g (41.9 mmol) of 1-methoxymethyl-2-(5-tetrazolylmethyl)-imidazole are refluxed in a mixture of 85 ml glacial acetic acid, 8.5 ml of water and 8.5 ml of conc. hydrochloric acid for 24 hours. The mixture is then concentrated in vacuo and the residue rapidly dried to a far extent in a high vacuum over potassium hydroxide and conc. sulphuric acid. The acid addition salt obtained is decomposed with the stoichiometric quantity of sodium ethoxide in an ethanolic solution. After removal of the sodium chloride precipitated, the solvent is distilled off and the residue recrystallised from methanol at boiling heat with the addition of a little ether.

Workup

  1. concentrationThe mixture is then concentrated in vacuo
  2. dry with materialthe residue rapidly dried to a far extent in a high vacuum over potassium hydroxide and conc. sulphuric acid
  3. additionThe acid addition salt
  4. customobtained
  5. customAfter removal of the sodium chloride
  6. customprecipitated
  7. distillationthe solvent is distilled off
  8. customthe residue recrystallised from methanol
  9. temperatureat boiling heat with the addition of a little ether

Sources & evidence

ORD record
ord-899fa30539334edf93737f2d33aa847d
Source dataset
uspto-grants-1980_07
Patent number
US04213986

Reaction notes

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