5,11-Dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one → 11-(6-chlorocaproyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

HRID 2057913Notes

Reaction equation

HRID 2057913 reaction equation
[N:1]1[C:6]2[NH:7][C:8]3[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=3[C:10](=[O:12])[NH:11][C:5]=2[CH:4]=[CH:3][CH:2]=1.[Cl:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][C:23](Cl)=[O:24]>C1(C)C(C)=CC=CC=1>[Cl:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][C:23]([N:7]1[C:8]2[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=2[C:10](=[O:12])[NH:11][C:5]2[CH:4]=[CH:3][CH:2]=[N:1][C:6]1=2)=[O:24]

Participants

4

Reactant 2

HCID 701695,11-Dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-oneHCID 880146-Chlorohexanoyl chloride

Product 1

HCID 1592430211-(6-chlorocaproyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

A solution of 5,11-dihydro-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-one and 6-chloro-caproyl chloride in xylene was reacted to obtain 11-(6-chloro-caproyl)-5,11-dihydro-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-one melting at 128°-130° C.

Sources & evidence

ORD record
ord-004e6a4c734f4951aab5e939b95627e5
Source dataset
uspto-grants-1980_07
Patent number
US04213985

Reaction notes

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