Diethylamine → HCID 20329345, compound

HRID 2057917Notes

Reaction equation

HRID 2057917 reaction equation
O[CH2:2][C:3]1[N:7]2[C:8]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:9]=3[N:10]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:11](=[O:13])[CH2:12][C:6]2=[N:5][N:4]=1.CS([O-])(=O)=O.[CH2:30]([NH:32][CH2:33][CH3:34])[CH3:31]>CS(C)=O.C(Cl)Cl>[CH2:30]([N:32]([CH2:2][C:3]1[N:7]2[C:8]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:9]=3[N:10]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:11](=[O:13])[CH2:12][C:6]2=[N:5][N:4]=1)[CH2:33][CH3:34])[CH3:31]

Participants

6

Reactant 3

HCID 8021DiethylamineHCID 85257MethanesulfonateHCID 20329310HCID 20329310, compound

Product 1

HCID 20329345HCID 20329345, compound

Reagents, catalysts & solvents 2

HCID 679Dimethyl SulfoxideSolvent2×HCID 6344DichloromethaneSolvent

Procedure

3.35 g of 1-(Hydroxymethyl)-8-chloro-6-phenyl-4H-s-triazolo[4,3-a][1,5]benzodiazepin-5-one, methanesulfonate in 15 ml dimethylsulfoxide at 0° is added dropwise with stirring to 3 ml of diethylamine in 10 ml dimethylsulfoxide. The reaction is stirred at 20° for 2 hours, diluted with methylene chloride, washed with water and then saturated aqueous sodium chloride. After drying, the solvent is evaporated to give the title compound.

Workup

  1. washwashed with water
  2. customAfter drying
  3. customthe solvent is evaporated

Sources & evidence

ORD record
ord-6e0d82dc35b34ca8a7d4e451861235f8
Source dataset
uspto-grants-1980_07
Patent number
US04213982

Reaction notes

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