HCID 20329754, compound → HCID 20329796, compound

HRID 2058051Notes

Reaction equation

HRID 2058051 reaction equation
[N+:1]([C:4]1[CH:13]=[C:12]2[C:7]([CH2:8][CH2:9][CH2:10][CH:11]2[C:14]([O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:15])=[CH:6][CH:5]=1)([O-])=O>C(OCC)(=O)C.[C].[Pd]>[NH2:1][C:4]1[CH:13]=[C:12]2[C:7]([CH2:8][CH2:9][CH2:10][CH:11]2[C:14]([O:16][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[O:15])=[CH:6][CH:5]=1

Participants

4

Reactant 1

HCID 20329754HCID 20329754, compound

Product 1

HCID 20329796HCID 20329796, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A 1.0-g portion of the phenyl 7-nitro-1,2,3,4-tetrahydro-1-naphthoate obtained above was catalytically reduced with 5% palladium-carbon in ethyl acetate. After removal of the catalyst by filtration, the ethyl acetate was removed by distillation under reduced pressure. The residue was recrystallized from methanol to obtain 550 mg of phenyl 7-amino-1,2,3,4-tetrahydro-1-naphthoate, m.p. 89°-90° C.

Workup

  1. customAfter removal of the catalyst
  2. filtrationby filtration
  3. customthe ethyl acetate was removed by distillation under reduced pressure
  4. customThe residue was recrystallized from methanol

Sources & evidence

ORD record
ord-d80d3cc7ed1d4c0d8dd620d325ba7bdb
Source dataset
uspto-grants-1980_07
Patent number
US04214093

Reaction notes

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