反应详情

A solution of 4-methoxypyrimidine (12.9 g, 0.117 mole) and unsym-dimethylethylene diamine (20.7 g, 0.23 mole) in 40 ml of xylene is heated under reflux for 64 hours. The reaction is concentrated and the oil is distilled at 15 mm of Hg. 4-(2-Dimethylaminoethylamino) pyrimidine, boiling at 164°-169° C., is collected.

1. temperatureunder reflux for 64 hours
2. concentrationThe reaction is concentrated
3. distillationthe oil is distilled at 15 mm of Hg
4. custom4-(2-Dimethylaminoethylamino) pyrimidine, boiling at 164°-169° C., is collected