Hydrochloric Acid → HCID 70515775, compound

HRID 2058543Notes

Reaction equation

HRID 2058543 reaction equation
[NH2:1][C:2]1[C:3]([C:9]([OH:11])=[O:10])=[CH:4][S:5][C:6]=1[CH2:7][CH3:8].[ClH:12].[CH:13](O)([CH3:15])[CH3:14]>>[ClH:12].[CH:13]([O:10][C:9]([C:3]1[C:2]([NH2:1])=[C:6]([CH2:7][CH3:8])[S:5][CH:4]=1)=[O:11])([CH3:15])[CH3:14]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 132861554-Amino-5-ethylthiophene-3-carboxylic acid

Product 1

HCID 70515775HCID 70515775, compound

Procedure

A sample of 1.02 g. (4.610 mmols) of 4-amino-5-ethyl-3-thiophenecarboxylic acid was dissolved in 50 ml. of isopropanol which had been previously saturated with gaseous hydrogen chloride. The resulting reaction was heated under reflux for 48 hours, cooled and evaporated to afford 0.927 g. (81%) of pure 4-amino-5-ethyl-3-thiophenecarboxylic acid isopropyl ester hydrochloride, m.p. 159° C. (dec.) after recrystallization from isoprpopanol/ether.

Workup

  1. customThe resulting reaction
  2. temperaturewas heated
  3. temperatureunder reflux for 48 hours
  4. temperaturecooled
  5. customevaporated
  6. customto afford 0.927 g
  7. custom(81%) of pure 4-amino-5-ethyl-3-thiophenecarboxylic acid isopropyl ester hydrochloride, m.p. 159° C. (dec.) after recrystallization from isoprpopanol/ether

Sources & evidence

ORD record
ord-f8d734479dae4dd4b8d467a5adbad9b1
Source dataset
uspto-grants-1982_03
Patent number
US04317915

Reaction notes

Loading…