反应详情

A solution of 219 mg. (1 mmol) of N-(1,2,3,4-tetrahydro-8-methoxy-2-naphthalenyl) acetamide in 7.5 ml. of trifluoroacetic acid was treated with 140 mg. of sodium nitrate in one portion. It was stirred for one hour at room temperature, poured into excess sodium bicarbonate solution and extracted well with methylene chloride. The combined extracts were washed with water, dried and evaporated to give crystals. Recrystallization from ethyl acetate gave N-(1,2,3,4-tetrahydro-8-methoxy-5-nitro-2-naphthalenyl) acetamide as white crystals m.p. 205°-206°.

1. extractionextracted well with methylene chloride
2. washThe combined extracts were washed with water
3. customdried
4. customevaporated
5. customto give crystals
6. customRecrystallization from ethyl acetate