Hydrochloric Acid → HCID 20545851, compound

HRID 2059127Notes

Reaction equation

HRID 2059127 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([O:21][CH3:22])[C:17]([O:19][CH3:20])=[CH:18][C:13]=2[CH2:12][C:11]([CH3:23])=[N:10][N:9]=1.Cl>C(O)C>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([O:21][CH3:22])[C:17]([O:19][CH3:20])=[CH:18][C:13]=2[CH2:12][C:11]([CH3:23])=[N:10][N:9]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15587240HCID 15587240, compound

Product 1

HCID 20545851HCID 20545851, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

One proceeds as described in Example 18 with the difference that 2-acetonyl-4,5-dimethoxy-2'-chlorobenzopnenone is applied as starting substance. The resulting crude 1-(2-chlorophenyl)-4-methyl-7,8-dimethoxy-5H-2,3-benzodiazepine is treated with absolute ethanol containing hydrochloric acid to obtain the pure hydrochloride. [C18H18ClN2O2 ]Cl=365.5. The title compound decomposes at 186°-188° C. after recrystallization from absolute ethanol and ether.

Sources & evidence

ORD record
ord-58e2487682c241309611dff946d0f32b
Source dataset
uspto-grants-1982_03
Patent number
US04322346

Reaction notes

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