Hydrochloric Acid → HCID 86738313, compound

HRID 2059174Notes

Reaction equation

HRID 2059174 reaction equation
[CH3:1][C:2]1[C:11]2[C:6]3=[C:7]([S:22][CH2:23][CH2:24][N:5]3[C:4](=[O:25])[CH:3]=1)[CH:8]=[C:9]([C:12]([OH:21])([C:17]([F:20])([F:19])[F:18])[C:13]([F:16])([F:15])[F:14])[CH:10]=2.C(Cl)(=[O:28])C.Cl>N1C=CC=CC=1>[C:12]([OH:21])(=[O:28])[CH3:17].[CH3:1][C:2]1[C:11]2[C:6]3=[C:7]([S:22][CH2:23][CH2:24][N:5]3[C:4](=[O:25])[CH:3]=1)[CH:8]=[C:9]([C:12]([OH:21])([C:13]([F:16])([F:14])[F:15])[C:17]([F:18])([F:19])[F:20])[CH:10]=2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6367Acetyl chlorideHCID 13036821HCID 13036821, compound

Product 1

HCID 86738313HCID 86738313, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution of 2,3-dihydro-7-methyl-9-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-5H-1,4-thiazino[2,3,4-ij]-quinolin-5-one in dry pyridine can be added acetyl chloride. The solution is heated at reflux, and when the reaction is complete, the solution can be poured into cold 1 N hydrochloric acid solution, extracted, isolated and purified to give 2,3-dihydro-7-methyl-9-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-5H-1,4-thiazino-[2,3,4-ij]-quinolin-5-one acetate.

Workup

  1. temperatureThe solution is heated
  2. temperatureat reflux
  3. extractionextracted
  4. customisolated
  5. custompurified

Sources & evidence

ORD record
ord-6d9bafa825fc49a9ab1eea5cefc71e25
Source dataset
uspto-grants-1982_03
Patent number
US04322417

Reaction notes

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