Ethanol → HCID 20546018, compound

HRID 2059175Notes

Reaction equation

HRID 2059175 reaction equation
[CH3:1][C:2]1[C:11]2[C:6]3=[C:7]([S:22][CH2:23][CH2:24][N:5]3[C:4](=[O:25])[CH:3]=1)[CH:8]=[C:9]([C:12]([OH:21])([C:17]([F:20])([F:19])[F:18])[C:13]([F:16])([F:15])[F:14])[CH:10]=2.[H-].[Na+].S(OC)(O[CH3:32])(=O)=O.C(O)C>CN(C)C=O>[CH3:1][C:2]1[C:11]2[C:6]3=[C:7]([S:22][CH2:23][CH2:24][N:5]3[C:4](=[O:25])[CH:3]=1)[CH:8]=[C:9]([C:12]([O:21][CH3:32])([C:13]([F:14])([F:15])[F:16])[C:17]([F:20])([F:18])[F:19])[CH:10]=2

Participants

6

Reactant 4

HCID 702EthanolHCID 6497Dimethyl SulfateHCID 24758Sodium hydrideHCID 13036821HCID 13036821, compound

Product 1

HCID 20546018HCID 20546018, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 2,3-dihydro-7-methyl-9-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-5H-1,4-thiazino-[2,3,4-ij]-quinolin-5-one in dimethyl formamide can be added sodium hydride and dimethyl sulfate. The mixture can be stirred and heated in a nitrogen atmosphere until the reaction is complete, treated with ethanol and purified to give 2,3-dihydro-7-methyl-9-[2,2,2-trifluoro-1-methoxy-1-(trifluoromethyl)ethyl]-5H-1,4-thiazino-[2,3,4-ij]-quinolin-5-one.

Workup

  1. temperatureheated in a nitrogen atmosphere until the reaction
  2. custompurified

Sources & evidence

ORD record
ord-8e26ba86ead145b6b8c313f6b5239e49
Source dataset
uspto-grants-1982_03
Patent number
US04322417

Reaction notes

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