Hydroxyamine hydrochloride → HCID 12960032, compound

HRID 2059221Notes

Reaction equation

HRID 2059221 reaction equation
[C:1]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:6]=[CH:5][C:4]([C:7]([O:11]C)=[CH:8][C:9]#[N:10])=[CH:3][CH:2]=1.C1(C2C=CC=CC=2)C=CC(C(OC)(OC)CC#[N:28])=CC=1.Cl.NO.C[O-].[Na+]>CO>[C:1]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:6]=[CH:5][C:4]([C:7]2[O:11][N:10]=[C:9]([NH2:28])[CH:8]=2)=[CH:3][CH:2]=1

Participants

6

Reactant 4

HCID 443297Hydroxyamine hydrochlorideHCID 10942334Sodium MethoxideHCID 12960031HCID 12960031, compoundHCID 54142171HCID 54142171, compound

Product 1

HCID 12960032HCID 12960032, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3-(4-Biphenylyl)-3-methoxyacrylonitrile plus 3-(4-biphenylyl)-3,3-dimethoxypropionitrile (2.9 grams as a mixture from example 6), hydroxylamine hydrochloride (4.7 grams), and sodium methoxide (11.9 grams) were mixed in 500 ml. of methanol and refluxed for 48 hours. After the methanol was evaporated, water was added and the product, separated by filtration, yielded 1.2 grams. NMR confirmed the identity of the product.

Workup

  1. customAfter the methanol was evaporated
  2. additionwater was added
  3. customthe product, separated by filtration
  4. customyielded 1.2 grams

Sources & evidence

ORD record
ord-7b496d828ed1407b8fb38fa3b051e77b
Source dataset
uspto-grants-1982_03
Patent number
US04322429

Reaction notes

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