4-(Trifluoromethyl)phenylacetonitrile → 3-Dimethylamino-2-(4-(trifluoromethyl)phenyl)-acrylonitrile

HRID 2059231Notes

Reaction equation

HRID 2059231 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]#[N:11])=[CH:5][CH:4]=1.CO[CH:16](OC)[N:17]([CH3:19])[CH3:18]>O>[CH3:18][N:17]([CH3:19])[CH:16]=[C:9]([C:6]1[CH:5]=[CH:4][C:3]([C:2]([F:1])([F:12])[F:13])=[CH:8][CH:7]=1)[C:10]#[N:11]

Participants

4

Reactant 2

HCID 753594-(Trifluoromethyl)phenylacetonitrileHCID 78373Dimethylformamide dimethyl acetal

Product 1

HCID 544907463-Dimethylamino-2-(4-(trifluoromethyl)phenyl)-acrylonitrile

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

4-(Trifluoromethyl)phenylacetonitrile (6.0 g.) in 5 ml. dimethylformamide-dimethylacetal was refluxed for 2 hours. Water was added and the final product was filtered, dried, and identified by NMR analysis.

Workup

  1. filtrationthe final product was filtered
  2. customdried

Sources & evidence

ORD record
ord-93734f19b9c1410e96a1cf334af61743
Source dataset
uspto-grants-1982_03
Patent number
US04322429

Reaction notes

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