Epichlorohydrin → HCID 20545910, compound

HRID 2059320Notes

Reaction equation

HRID 2059320 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[C:17]3[C:12](=[CH:13][C:14]([OH:18])=[CH:15][CH:16]=3)[C:11](=[O:19])[C:10]([CH3:21])([CH3:20])[CH2:9]2)=[CH:4][CH:3]=1.[CH2:22]([CH:24]1[O:26][CH2:25]1)Cl.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[C:17]3[C:12](=[CH:13][C:14]([O:18][CH2:22][CH:24]4[O:26][CH2:25]4)=[CH:15][CH:16]=3)[C:11](=[O:19])[C:10]([CH3:21])([CH3:20])[CH2:9]2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 7835EpichlorohydrinHCID 11430Potassium CarbonateHCID 20545898HCID 20545898, compound

Product 1

HCID 20545910HCID 20545910, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 4(4-chlorophenyl)-7-hydroxy-2,2-dimethyl-1-tetralone (17.6 g), epichlorohydrin (30 ml) and potassium carbonate (6.0 g) was heated under reflux in acetone (30 ml) for 24 hr. The hot mixture was filtered and evaporation of the filtrate in vacuo gave 4-(4-chlorphenyl)-7-(2,3-epoxypropoxy)-2,2-dimethyl-1-tetralone as a light yellow gum (8.4 g, 93%).

Workup

  1. temperaturewas heated
  2. filtrationThe hot mixture was filtered
  3. customevaporation of the filtrate in vacuo

Sources & evidence

ORD record
ord-6e381eb75c73498691977b0a71a746c2
Source dataset
uspto-grants-1982_03
Patent number
US04322370

Reaction notes

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