tert-butyl N-(2-oxoethyl)carbamate → HCID 178477509, compound

HRID 2059489Notes

Reaction equation

HRID 2059489 reaction equation
CC(C)(C)OC(=O)NCC=O.CCSC(=O)C(F)C(=O)O>C1COCCN1.CN(C)c1ccncc1.C1CCOC1>CCSC(=O)/C(F)=C/CNC(=O)OC(C)(C)C

Participants

6

Reactant 2

HCID 4247255tert-butyl N-(2-oxoethyl)carbamateHCID 178477510HCID 178477510, compound

Product 1

HCID 178477509HCID 178477509, compoundYield 15%

Reagents, catalysts & solvents 3

HCID 142844-(Dimethylamino)pyridineReagentHCID 8083MorpholineCatalystHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
25 °C

Workup

  1. temperatureThe product mixture was cooled to 25 °C.
  2. filtrationFiltered through a pad of celite · Keep Organic
  3. wash"The celite was washed with ethyl acetate (3 x 1 mL)."
  4. concentrationThe filtrate was concentrated under reduced pressure
  5. additionA 0.07 M stock solution of the internal standard ethylene carbonate (0.70 mL in CDCl3) was added.

Sources & evidence

ORD record
ord-6baf78359a0e4cd58619176684f29830
Source dataset
Transfer learning optimization of 26 decarboxylative olefination reactions

Reaction notes

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