HCID 67542813, compound → HCID 25260754, compound

HRID 2059714Notes

Reaction equation

HRID 2059714 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[NH:9][C:10]1[N:14]2[CH:15]=[CH:16][CH:17]=[N:18][C:13]2=[N:12][C:11]=1[C:19]1[C:35]([O:36][CH3:37])=[CH:34][C:33]([O:38][CH3:39])=[CH:32][C:20]=1[C:21]([NH:23][NH:24]C(OC(C)(C)C)=O)=[O:22]>Cl.O1CCOCC1>[Cl:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[C:3]=1[NH:9][C:10]1[N:14]2[CH:15]=[CH:16][CH:17]=[N:18][C:13]2=[N:12][C:11]=1[C:19]1[C:35]([O:36][CH3:37])=[CH:34][C:33]([O:38][CH3:39])=[CH:32][C:20]=1[C:21]([NH:23][NH2:24])=[O:22]

Participants

4

Reactant 1

HCID 67542813HCID 67542813, compound

Product 1

HCID 25260754HCID 25260754, compoundYield 84%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

3.2 120 mg of tert-butyl N′-{2-[3-(2,6-dichlorophenylamino)imidazo[1,2-a]-pyrimidin-2-yl]-3,5-dimethoxybenzoyl}hydrazinecarboxylate are stirred at RT for 1 hour in 3 ml of 4 N HCl in dioxane. The reaction mixture is evaporated, the residue is triturated with a little ethyl acetate and filtered off with suction, giving 90 mg (84%) of 2-[3-(2,6-dichlorophenylamino)imidazo-[1,2-a]pyrimidin-2-yl]-3,5-dimethoxybenzohydrazide as hydrochloride; MS-FAB (M+H+)=474.3; Rf (polar method): 1.33 min.

Workup

  1. customThe reaction mixture is evaporated
  2. customthe residue is triturated with a little ethyl acetate
  3. filtrationfiltered off with suction

Sources & evidence

ORD record
ord-2f8136104caf4a2cbd92889e1b31cb71
Source dataset
uspto-grants-2012_10
Patent number
US08278312B2

Reaction notes

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