Trifluoroacetic acid → HCID 57989597, compound

HRID 2059890Notes

Reaction equation

HRID 2059890 reaction equation
C(O)(C(F)(F)F)=O.[CH3:8][O:9][C:10]1[CH:15]=[C:14]([CH3:16])[C:13]([S:17]([N:20]2[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH2:22][C@H:21]2[CH2:29][O:30][CH2:31][C:32]([O:34]C(C)(C)C)=[O:33])(=[O:19])=[O:18])=[C:12]([CH3:39])[CH:11]=1>C(Cl)Cl>[CH3:8][O:9][C:10]1[CH:15]=[C:14]([CH3:16])[C:13]([S:17]([N:20]2[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH2:22][C@H:21]2[CH2:29][O:30][CH2:31][C:32]([OH:34])=[O:33])(=[O:19])=[O:18])=[C:12]([CH3:39])[CH:11]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57989587HCID 57989587, compound

Product 1

HCID 57989597HCID 57989597, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

TFA (1.5 ml) was added to a cooled (0° C.) solution of (S)-tert-butyl 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)indolin-2-yl)methoxy)acetate (0.5 mmol) in DCM (6 ml) and the mixture was stirred for 2 h at room temperature. The solvent was removed under vacuum and the residue used in the subsequent stage.

Workup

  1. customThe solvent was removed under vacuum

Sources & evidence

ORD record
ord-894bb953def5409ba4d05001bc6fda38
Source dataset
uspto-grants-2012_10
Patent number
US08278319B2

Reaction notes

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