Ethyl formate → HCID 59370483, compound

HRID 2059932Notes

Reaction equation

HRID 2059932 reaction equation
[CH3:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:10][CH2:11][NH2:12].[CH:13](OCC)=[O:14]>>[CH3:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:10][CH2:11][NH:12][CH:13]=[O:14]

Participants

3

Reactant 2

HCID 8025Ethyl formateHCID 59994483HCID 59994483, compound

Product 1

HCID 59370483HCID 59370483, compound

Procedure

{2-[2-Methyl-3-(methyloxy)phenyl]ethyl}amine (Preparation 10; 1.75 g; 10.6 mmol) was heated under reflux with ethyl formate (97%; 15 ml) for 15 h. Removal of the solvent gave the crude product (ca. 2 g), which was purified by chromatography on silica gel, eluting with a gradient of 13-63% ethyl acetate in cyclohexane, to give the title compound (1.57 g).

Workup

  1. customRemoval of the solvent
  2. customgave the crude product (ca. 2 g), which
  3. customwas purified by chromatography on silica gel
  4. washeluting with a gradient of 13-63% ethyl acetate in cyclohexane

Sources & evidence

ORD record
ord-d2a04144588840a8b47bcf96600ea3f0
Source dataset
uspto-grants-2012_10
Patent number
US08278324B2

Reaction notes

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