反应详情

21.5 g of valsartan in 200 ml of isopropanol and 100 ml of water are stirred for ca. 3 hours at ca. 25° C. with 1.5 g of magnesium hydroxide and 1.9 g of calcium hydroxide. The practically clear solution is concentrated in a vacuum at ca. 50° C. A total of 240 ml of ethyl acetate is added with stirring to the still warm, semi-solid residue which contains residual water. Upon stirring over night at ca. 25° C., initially sticky constituents are transformed into a homogeneous suspension. The suspension is filtered by suction and washed with 20 ml of ethyl acetate. The moist filter cake is dried in a vacuum at 30-40° C. A colourless crystal powder is obtained.

1. concentrationThe practically clear solution is concentrated in a vacuum at ca. 50° C
2. additionA total of 240 ml of ethyl acetate is added
3. temperaturestill warm
4. stirringUpon stirring over night at ca. 25° C.
5. filtrationThe suspension is filtered by suction
6. washwashed with 20 ml of ethyl acetate
7. customThe moist filter cake is dried in a vacuum at 30-40° C
8. customA colourless crystal powder is obtained