反应详情

温度

-70 °C

Lithium bis(trimethylsilyl)amide (1000 mL of a 1.0M solution in tetrahydrofuran, 1.0 mol) was added to a stirred solution of 1-(4-methoxy-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester (±) (268 g, 0.97 mol) (see Preparation 2) in THF (1600 mL) at −70° C. The mixture was stirred for 20 mins at −70° C. then ethyl chloroformate (104 mL, 1.09 mol) was added over 15 minutes. The resulting mixture was stirred at −60° C. for 1 hour. The reaction mixture was quenched with 10% citric acid aqueous solution (1200 mL) at −50° C. then warmed to room temperature. The organic layer was separated, washed with saturated aqueous NaHCO3 (1200 mL) and water (1200 mL) then concentrated under reduced pressure to afford the title compound as an orange oil (316.0 g, 94%).

1. stirringThe resulting mixture was stirred at −60° C. for 1 hour
2. customThe reaction mixture was quenched with 10% citric acid aqueous solution (1200 mL) at −50° C.
3. temperaturethen warmed to room temperature
4. customThe organic layer was separated
5. washwashed with saturated aqueous NaHCO3 (1200 mL) and water (1200 mL)
6. concentrationthen concentrated under reduced pressure