4-Hydroxyphenylboronic acid → 6-(4-Hydroxyphenyl)nicotinonitrile

HRID 2060243Notes

Reaction equation

HRID 2060243 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5](B(O)O)=[CH:4][CH:3]=1.Br[C:12]1[CH:17]=[CH:16][C:15]([C:18]#[N:19])=[CH:14][N:13]=1>>[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:12]2[CH:17]=[CH:16][C:15]([C:18]#[N:19])=[CH:14][N:13]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27343604-Hydroxyphenylboronic acidHCID 50057186-Bromopyridine-3-carbonitrile

Product 1

HCID 1357533786-(4-Hydroxyphenyl)nicotinonitrileYield 23%

Procedure

The title compound was prepared according to the method described for Preparation 17 using 4-hydroxybenzene boronic acid and 2-bromo-5-cyanopyridine to afford the title compound as a white solid (250 mg, 23%)

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-3b9ccf186e6b40b5bd8715a7d18adda7
Source dataset
uspto-grants-2012_10
Patent number
US08278343B2

Reaction notes

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