2,5-Dichloropyrimidine → 4-(5-Chloropyrimidin-2-yl)phenol

HRID 2060244Notes

Reaction equation

HRID 2060244 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5](B(O)O)=[CH:4][CH:3]=1.Cl[C:12]1[N:17]=[CH:16][C:15]([Cl:18])=[CH:14][N:13]=1>>[Cl:18][C:15]1[CH:14]=[N:13][C:12]([C:5]2[CH:6]=[CH:7][C:2]([OH:1])=[CH:3][CH:4]=2)=[N:17][CH:16]=1

Participants

3

Reactant 2

HCID 5906412,5-DichloropyrimidineHCID 27343604-Hydroxyphenylboronic acid

Product 1

HCID 1360525824-(5-Chloropyrimidin-2-yl)phenolYield 29%

Procedure

The title compound was prepared according to the method described for Preparation 17 using 4-hydroxybenzene boronic acid and 2,5-dichloro-pyrimidine to afford the title compound as a pale yellow solid (1.91 g, 29%)

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-12d4b1e1afe441e9a55120ad26a9d100
Source dataset
uspto-grants-2012_10
Patent number
US08278343B2

Reaction notes

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