Potassium Hydroxide → Potassium 1-[(6-bromopyridin-2-yl)methyl]-1,2,3-triazole-4-carboxylate

HRID 2060605Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2060605
[Br:1][C:2]1[N:7]=[C:6]([CH2:8][N:9]2[CH:13]=[C:12]([C:14]([O:16]C)=[O:15])[N:11]=[N:10]2)[CH:5]=[CH:4][CH:3]=1.[OH-].[K+:19]>O1CCCC1.CO>[Br:1][C:2]1[N:7]=[C:6]([CH2:8][N:9]2[CH:13]=[C:12]([C:14]([O-:16])=[O:15])[N:11]=[N:10]2)[CH:5]=[CH:4][CH:3]=1.[K+:19]

Komponenten

5

Edukt 2

HCID 14797Potassium HydroxideHCID 58335253Methyl 1-[(6-bromopyridin-2-yl)methyl]-1H-1,2,3-triazole-4-carboxylate

Produkt 1

HCID 86655085Potassium 1-[(6-bromopyridin-2-yl)methyl]-1,2,3-triazole-4-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of methyl 1-[(6-bromopyridin-2-yl)methyl]-1H-1,2,3-triazole-4-carboxylate (840 mg, 2.83 mmol) in tetrahydrofuran (6.0 mL) and methanol (3.0 mL) was added 1 M aqueous potassium hydroxide (3.11 mL, 3.11 mmol). The solution was stirred at room temperature for 3 h, during which time it became a white slurry. The solvent was evaporated to afford the title salt as a colorless solid that was carried forward without purification. LRMS (APCI) calc'd for C9H8BrN4O2 [M+H]+: 283, Found: 283.

Aufarbeitung

  1. customThe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-0a52bdadfd554f29a72994e706e0a262
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08278335B2

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