反应详情

温度

100 °C

Phosphorous oxychloride (0.518 g, 17.7 mmol) was added to DMF (1.04 mL) under argon at rt. After 30 min 7-methoxybenzothiophene (0.5 g, 3.04 mmol) was added and the reaction was heated to 100° C. for 3.5 h. The reaction was cooled to rt and poured into a saturated Na2CO3 solution, extracted with ether (100 mL) and the organic phase dried (MgSO4). Solvent was removed in vacuo to give the title compound: RT=3.34 min; m/z (ES+)=193.2 [M+H]+.

1. temperatureThe reaction was cooled to rt
2. extractionextracted with ether (100 mL)
3. dry with materialthe organic phase dried (MgSO4)
4. customSolvent was removed in vacuo