反应详情

A mixture of ethoxymethylene malonic acid diethyl ester (20.1 mL, 0.10 mol) and 4-iodoaniline (22 g, 0.10 mole) in toluene (300 ml) was heated to reflux for 1 h. After this period of time, solvents were removed under vacuum, and the crude material was precipitated in methyl tert-butyl ether and the resulting white solid was filtered, and dried under vacuum to give 30 g product.

1. temperaturewas heated
2. temperatureto reflux for 1 h
3. customAfter this period of time, solvents were removed under vacuum
4. customthe crude material was precipitated in methyl tert-butyl ether
5. filtrationthe resulting white solid was filtered
6. customdried under vacuum