Phenylhydrazine → HCID 25217782, compound

HRID 2061898Notes

Reaction equation

HRID 2061898 reaction equation
C([O-])([O-])=O.[Cs+].[Cs+].Cl[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[C:14]#[C:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.[C:22]1([NH:28][NH2:29])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>Cl[Pd]Cl.CN(C=O)C>[CH2:15]([C:14]1[N:28]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[N:29]=[C:8]2[C:9]=1[CH:10]=[CH:11][CH:12]=[CH:13]2)[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

6

Reactant 3

HCID 7516PhenylhydrazineHCID 10796Cesium carbonateHCID 251161-Chloro-2-(phenylethynyl)benzene

Product 1

HCID 25217782HCID 25217782, compoundYield 81%

Reagents, catalysts & solvents 2

HCID 24290Palladium ChlorideCatalystHCID 6228DimethylformamideSolvent

Conditions

Temperature
130 °C

Procedure

Following the general procedure outlined above, a reaction tube was charged with 4.4 mg PdCl2 (5 mol %), 14.5 mg tBu3PHBF4 (10 mol %), 228.1 mg Cs2CO3 (1.4 equiv.) and 2.5 mL DMF. After stirring for 30 min at RT under a flow of argon, 1-chloro-2-phenylethynyl-benzene (106.3 mg, 1.0 equiv.) and phenylhydrazine (75.7 mg, 1.4 equiv.) were added and the reaction was heated to 130° C. for 3 hours. After cooling to RT, the reaction mixture was quenched with brine (30 mL) and extracted with EtOAc (2×30 mL) and the organic phase was dried by eluting through a Varian Chem Elut 12198007 cartridge. Removal of the solvents afforded the crude indazole as a dark-brown oil that purified by FC on silica using CH2Cl2/EtOAc to afford 115.0 mg (81%) of 3-benzyl-2-phenyl-2H-indazole colorless oil that solidified upon standing. 1H-NMR (DMSO-d6) δ 4.47 (s, 2H), 6.98 (d, 2H, J=7.1 Hz), 7.03 (dd, 1H, J=7.9, 7.0 Hz), 7.13-7.24 (m, 3H), 7.30 (dd, 1H, J=8.1, 7.0 Hz), 7.52-7.58 (m, 5H), 7.60 (d, 1H, J=8.6 Hz), 7.65 (d, 1H, J=8.6 Hz); 13C-NMR (DMSO-d6) δ 30.4, 117.1, 120.5, 121.0, 121.2, 125.9 (2C), 126.3, 126.4, 128.1 (2C), 128.4 (2C), 128.9, 129.2 (2C), 134.5, 137.9, 139.5, 147.9; HRMS (FAB): Calculated for C20H17N2 (M+H+) 285.1391, found 285.1385.

Workup

  1. additionwere added
  2. temperatureAfter cooling to RT
  3. customthe reaction mixture was quenched with brine (30 mL)
  4. extractionextracted with EtOAc (2×30 mL)
  5. customthe organic phase was dried
  6. washby eluting through a Varian Chem Elut 12198007 cartridge
  7. customRemoval of the solvents
  8. customafforded the crude indazole as a dark-brown oil
  9. customthat purified by FC on silica

Sources & evidence

ORD record
ord-431529c1a935446f863ffe5e88106cc5
Source dataset
uspto-grants-2012_10
Patent number
US08283476B2

Reaction notes

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