反应详情

A mixture of 2,3-dichloro-1,4-naphthoquinone (5 gm), trans 4-(4-chlorophenyl)-cyclohexane-1-carboxylic acid (6.06 gm) and silver nitrate (2.47 gm) is taken in acetonitrile (60 ml) and the mixture is heated to reflux, maintaining good stirring. Then a solution of ammonium persulphate (14.23 gm) in water (77 ml) is added through a dropping funnel over a period of 1-2 hrs. The mixture refluxed for 4 hrs. Then it is cooled in ice for about 1 hr after which it is filtered. The solid is extracted with hot methylene chloride (100 ml×3). The organic layer is dried over anhydrous sodium sulphate and concentrated to get light brownish yellow solid. This on crystallization from acetonitrile afforded the trans compound as yellow crystals (1.5 gm).

1. temperaturethe mixture is heated
2. temperatureto reflux
3. temperaturemaintaining good stirring
4. temperatureThe mixture refluxed for 4 hrs
5. temperatureThen it is cooled in ice for about 1 hr after which it
6. filtrationis filtered
7. extractionThe solid is extracted with hot methylene chloride (100 ml×3)
8. dry with materialThe organic layer is dried over anhydrous sodium sulphate
9. concentrationconcentrated
10. customto get light brownish yellow solid
11. customThis on crystallization from acetonitrile