Ethylene Glycol → HCID 68655173, compound

HRID 2063168Notes

Reaction equation

HRID 2063168 reaction equation
[NH2:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1.C(O)CO.[F:14][C:15]([F:20])([F:19])[C:16]([OH:18])=[O:17]>C(#N)C>[F:14][C:15]([F:20])([F:19])[C:16]([O-:18])=[O:17].[NH2:1][CH2:2][CH2:3][NH+:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1

Participants

5

Reactant 3

HCID 174Ethylene GlycolHCID 6422Trifluoroacetic acidHCID 8795Aminoethylpiperazine

Product 1

HCID 68655173HCID 68655173, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

12.92 g (0.1 mol) of 1-(2-aminoethyl)piperazine and 50 g of ethylene glycol or acetonitrile as an organic solvent were put into a 250 ml two-necked flask equipped with a condenser, and 11.4 g (0.1 mol) of trifluoroacetic acid was slowly added dropwise thereto. The resulting solution was stirred at room temperature for 4 hours, washed with diethyl ether several times, and then dried under vacuum, thus obtaining 1-(2-aminoethyl)piperazinium trifluoroacetate (yield: 86%).

Workup

  1. customequipped with a condenser
  2. washwashed with diethyl ether several times

Sources & evidence

ORD record
ord-03e164187ff34a759480000b561a405f
Source dataset
uspto-grants-2012_10
Patent number
US08287627B2

Reaction notes

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