Hydrochloric Acid → HCID 68811648, compound

HRID 2063483Notes

Reaction equation

HRID 2063483 reaction equation
[Cl:1][C:2]1[CH:26]=[CH:25][C:5]([CH2:6][C:7]2[C:8]([C@H:13]3[CH2:17][CH2:16][CH2:15][N:14]3C(OC(C)(C)C)=O)=[N:9][CH:10]=[N:11][CH:12]=2)=[CH:4][CH:3]=1.Cl>O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:26]=[CH:25][C:5]([CH2:6][C:7]2[C:8]([C@H:13]3[CH2:17][CH2:16][CH2:15][NH:14]3)=[N:9][CH:10]=[N:11][CH:12]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57650547HCID 57650547, compound

Product 1

HCID 68811648HCID 68811648, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

(R)-tert-butyl 2-(5-(4-chlorobenzyl)pyrimidine-4-yl)pyrrolidine-1-carboxylate from step C was treated with 4M HCl in dioxane (10 mL) for 2 h. Removal of the solvent in vacuo gave the product in quantitative yield as an oil, which was used in the next step without purification. MS: calculated: 273.1 found (MH+): 274.3.

Workup

  1. customRemoval of the solvent in vacuo
  2. customgave the product in quantitative yield as an oil, which
  3. customwas used in the next step without purification

Sources & evidence

ORD record
ord-8f6623f4f01b4c73991842e524f17716
Source dataset
uspto-grants-2012_10
Patent number
US08288371B2

Reaction notes

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