Hydrochloric Acid → 1-(3-Methoxypyridin-2-yl)-[1,4]diazepane dihydrochloride

HRID 2063540Notes

Reaction equation

HRID 2063540 reaction equation
[CH3:1][O:2][C:3]1[C:4]([N:9]2[CH2:15][CH2:14][CH2:13][N:12](C(O)=O)[CH2:11][CH2:10]2)=[N:5][CH:6]=[CH:7][CH:8]=1.[ClH:19].O1CCOCC1>CO>[ClH:19].[ClH:19].[CH3:1][O:2][C:3]1[C:4]([N:9]2[CH2:15][CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[N:5][CH:6]=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 675444874-(3-Methoxypyridin-2-yl)-[1,4]diazepane-1-carboxylic acid

Product 1

HCID 668934111-(3-Methoxypyridin-2-yl)-[1,4]diazepane dihydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 4-(3-methoxypyridin-2-yl)-[1,4]diazepane-1-carboxylic acid tent-butyl ester (335 mg, 1.1 mmol) was added MeOH (3 mL) followed by 4M HCl in dioxane (5 mL, 20 mmol). This was stirred for 15 hours, then concentrated to give the title compound. MS (ES) m/z 208 (M+H+).

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-75d15fc797ee4129bb01189ee67dc356
Source dataset
uspto-grants-2012_10
Patent number
US08288373B2

Reaction notes

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