Triethylamine → HCID 73320032, compound

HRID 2063596Notes

Reaction equation

HRID 2063596 reaction equation
Cl.Cl.[NH:3]([C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[C:7]([CH3:15])[N:6]=1)[NH2:4].C(N(CC)CC)C.[CH3:23][C:24]1[CH:29]=[C:28]([C:30]([CH3:32])=O)[CH:27]=[CH:26][CH:25]=1>C(O)C>[CH3:15][C:7]1[N:6]=[C:5]([NH:3][N:4]=[C:30]([C:28]2[CH:29]=[C:24]([CH3:23])[CH:25]=[CH:26][CH:27]=2)[CH3:32])[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 114553-MethylacetophenoneHCID 60209693HCID 60209693, compound

Product 1

HCID 73320032HCID 73320032, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared from 4-hydrazino-2-methylquinazoline dihydrochloride (250 mg, 1.01 mmol), triethylamine (0.35 mL, 2.02 mmol) and 3-methylacetophenone (0.35 mL, 2.63 mmol) in ethanol (5 mL) by a procedure similar to Example 4, step 4 yielding 11 mg (4%) of a yellow solid. HPLC Purity: 95%.

Sources & evidence

ORD record
ord-a659e713dfe942a69426e162dd14e154
Source dataset
uspto-grants-2012_10
Patent number
US08288398B2

Reaction notes

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