Hydrazine → HCID 60209697, compound

HRID 2063609Notes

Reaction equation

HRID 2063609 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH3:15])[N:5]=[C:4]([CH2:16][CH3:17])[N:3]=1.[NH2:18][NH2:19].C(=O)([O-])[O-].[Na+].[Na+].C(=O)([O-])[O-].[K+].[K+]>O1CCOCC1>[CH2:16]([C:4]1[N:3]=[C:2]([NH:18][NH2:19])[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH3:15])[N:5]=1)[CH3:17]

Participants

6

Reactant 4

HCID 9321HydrazineHCID 10340Sodium CarbonateHCID 11430Potassium CarbonateHCID 59846662HCID 59846662, compound

Product 1

HCID 60209697HCID 60209697, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

[2-Ethyl-6-(2-methoxy-phenyl)-pyrimidin-4-yl]-hydrazine was prepared from 4-chloro-2-ethyl-6-(2-methoxy-phenyl)pyrimidine (0.91 g, 3.7 mmol), hydrazine (0.69 mL, 22 mmol), sodium carbonate (0.76 g, 7.1 mmol) and potassium carbonate (0.79 g, 5.5 mmol) in dioxane (10 mL) by a procedure similar to example 3, step 1 yielding 0.77 g (86%) of a white solid.

Sources & evidence

ORD record
ord-40bdab6633c241dd9a03c15667d202f9
Source dataset
uspto-grants-2012_10
Patent number
US08288398B2

Reaction notes

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